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PJ34 Hydrochloride

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Cat.No：IP2880 Solarbio

CAS：344458-15-7

Molecular Formula：C₁₇H₁₈ClN₃O₂

Molecular Weight：331.8

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	344458-15-7
Name	PJ34 Hydrochloride
Molecular Formula	C₁₇H₁₈ClN₃O₂
Molecular Weight	331.8
Solubility	Soluble in Water/DMSO
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD16618379
SMILES	O=C(NC(C=C1C2=C3C=CC=C2)=CC=C1NC3=O)CN(C)C.Cl
Target Point	PARP
Passage	Cell Cycle;DNA Damage/DNA Repair; Epigenetics
Background	PJ34 Hydrochloride is a PARP inhibitor.
Biological Activity	PJ34 hydrochloride 是 PARPl1/2 的抑制剂，IC50 值分别为 110 nM 和 86 nM。[1-3]
IC50	PARP-2:86nM;PARP-1:110nM;PARP:110nM [1-3]
Data Literature Source	[1]. Iwashita A，et al. A novel and potent poly(ADP-ribose) polymerase-1 inhibitor，FR247304 (5-chloro-2-[3-(4-phenyl-3，6-dihydro-1(2H)-pyridinyl)propyl]-4(3H)-quinazolinone)，attenuates neuronal damage in in vitro and in vivo models of cerebral ischemia. J Ph [2]. Haddad M，et al. Anti-inflammatory effects of PJ34，a poly(ADP-ribose) polymerase inhibitor，in transient focal cerebral ischemia in mice. Br J Pharmacol. 2006 Sep;149(1):23-30. [3]. Diani-Moore S，et al. NAD+ loss，a new player in AhR biology: prevention of thymus atrophy and hepatosteatosis by NAD+ repletion. Sci Rep. 2017 May 23;7(1):2268
Unit	Bottle
Specification	10mg 50mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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