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5-Methoxyflavone

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Cat.No：IM2280 Solarbio

CAS：42079-78-7

Molecular Formula：C₁₆H₁₂O₃

Molecular Weight：252.27

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	42079-78-7
Name	5-Methoxyflavone
Molecular Formula	C₁₆H₁₂O₃
Molecular Weight	252.27
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 255-652-0
MDL	MFCD00016942
SMILES	O=C1C=C(C2=CC=CC=C2)OC3=CC=CC(OC)=C13
Target Point	DNA/RNA Synthesis
Passage	Cell Cycle;DNA Damage/DNA Repair
Background	5-Methoxyflavone, a flavonoid, is a DNA polymerase-beta (DNA polymerase-beta) inhibitor and a neuroprotectant against beta-amyloid toxicity.
Biological Activity	5-Methoxyflavone，是一种类黄酮，是DNA polymerase-beta的抑制剂和 β-淀粉样蛋白毒性的神经保护剂。拥有中枢神经系统镇静剂的作用,通过调控嗜离子 GABAA 受体来实现。[1-3]
Data Literature Source	[1]. Merlo S， et al. Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity. J Nat Prod. 2015 Nov 25; 78 (11) :2704-11. [2]. Shanmugasundaram J， et al. Sedative-hypnotic like effect of 5-methoxyflavone in mice and investigation on possible mechanisms by in vivo and in silico methods. Biomed Pharmacother. 2018 Dec; 108:85-94. [3]. Wudtiwai B， et al. Methoxyflavone derivatives modulate the effect of TRAIL-induced apoptosis in human leukemic cell lines. J Hematol Oncol. 2011 Dec 21; 4:52.
Unit	Bottle
Specification	25mg 50mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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