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SB-743921

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Cat.No：IS2100 Solarbio

CAS：940929-33-9

Molecular Formula：C₃₁H₃₄Cl₂N₂O₃

Molecular Weight：553.52

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light yellow to yellow Solid

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Product Information

CAS	940929-33-9
Name	SB-743921
Molecular Formula	C₃₁H₃₄Cl₂N₂O₃
Molecular Weight	553.52
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Light yellow to yellow Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD18385010
SMILES	ClC1=CC2=C(C(C(CC3=CC=CC=C3)=C([C@@H](C(C)C)N(C(C4=CC=C(C=C4)C)=O)CCCN)O2)=O)C=C1.Cl
Target Point	Kinesin
Passage	Cytoskeleton
Background	SB743921 is a kinesin spindle protein (KSP) inhibitor.
Biological Activity	SB-743921 是一种有效的驱动蛋白 (Eg5) 抑制剂，Ki 值为 0.1 nM。[1-3]
Data Literature Source	[1]. Jeffrey R. Jackson，et al. A second generation KSP inhibitor，SB-743921，is a highly potent and active therapeutic in preclinical models of cancer. First AACR International Conference on Molecular Diagnostics in Cancer Therapeutic Development，Sep 12-15，2006. [2]. Yin Y，et al. Kinesin spindle protein inhibitor SB743921 induces mitotic arrest and apoptosis and overcomes imatinib resistance of chronic myeloid leukemia cells. Leuk Lymphoma. 2015 Jun;56(6):1813-20. [3]. Good JA，et al. Optimized S-trityl-L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models. J Med Chem. 2013 Mar 14;56(5):1878-93.
Unit	Bottle
Specification	2mg 5mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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