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Romidepsin

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Cat.No：IR0910 Solarbio

CAS：128517-07-7

Molecular Formula：C₂₄H₃₆N₄O₆S₂

Molecular Weight：540.7

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	128517-07-7
Name	Romidepsin
Molecular Formula	C₂₄H₃₆N₄O₆S₂
Molecular Weight	540.7
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD18433404
SMILES	C/C=C(NC([C@@H](CSSCC/C=C/[C@@H](O1)CC2=O)NC([C@@H](C(C)C)N2)=O)=O)/C(N[C@@H](C(C)C)C1=O)=O
Target Point	HDAC
Passage	DNA Damage/DNA Repair;Epigenetics;NF-κB
Background	Romidepsin is a potent HDAC1 and HDAC2 inhibitor.
Biological Activity	Romidepsin 是一种有效的 HDAC1 和 HDAC2 抑制剂，IC50 值分别为 36 nM 和 47 nM。[1-3]
IC50	HDAC1:36nM;HDAC2:47nM;HDAC4:510nM;HDAC6:14000nM [1-3]
Data Literature Source	[1]. Furumai R，et al. FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases. Cancer Res. 2002 Sep 1;62(17):4916-21. [2]. Blagosklonny MV，et al. Histone deacetylase inhibitors all induce p21 but differentially cause tubulin acetylation，mitotic arrest，and cytotoxicity. Mol Cancer Ther. 2002 Sep;1(11):937-41. [3]. Sasakawa Y，et al. Effects of FK228，a novel histone deacetylase inhibitor，on human lymphoma U-937 cells in vitro and in vivo. Biochem Pharmacol. 2002 Oct 1;64(7):1079-90.
Unit	Bottle
Specification	1mg 5mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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