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Ribociclib

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Cat.No：IR0860 Solarbio

CAS：1211441-98-3

Molecular Formula：C₂₃H₃₀N₈O

Molecular Weight：434.54

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light yellow to brown Solid

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Product Information

CAS	1211441-98-3
Name	Ribociclib
Molecular Formula	C₂₃H₃₀N₈O
Molecular Weight	434.54
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Light yellow to brown Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 1592732-453-0
MDL	MFCD27976795
SMILES	O=C(N(C)C)C(N1C2CCCC2)=CC(C1=N3)=CN=C3NC(N=C4)=CC=C4N5CCNCC5
Target Point	CDK4，CDK6
Passage	Cell Cycle
Background	Ribociclib is an active, highly specific CDK4/6 inhibitor.
Biological Activity	Ribociclib (LEE011) 是高选择性的 CDK4/6 抑制剂, IC50 分别为10 nM, 39 nM[1-3]。
IC50	CDK4:10nM (IC50) CDK6:39nM (IC50) [1-3]
Data Literature Source	[1]. VanArsdale T， et al. Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment. Clin Cancer Res. 2015 Jul 1; 21 (13) :2905-10. [2]. Rader J， et al. Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and Senescence in Neuroblastoma. Clin Cancer Res. 2013 Nov 15; 19 (22) :6173-82. [3]. Olanich ME， et al. CDK4 Amplification Reduces Sensitivity to CDK4/6 Inhibition in Fusion-Positive Rhabdomyosarcoma. Clin Cancer Res. 2015 Nov 1; 21 (21) :4947-59.
Unit	Bottle
Specification	5mg 10mg 20mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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