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Purvalanol A

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Cat.No：IP3290 Solarbio

CAS：212844-53-6

Molecular Formula：C₁₉H₂₅ClN₆O

Molecular Weight：388.89

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light yellow to yellow Solid

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Product Information

CAS	212844-53-6
Name	Purvalanol A
Molecular Formula	C₁₉H₂₅ClN₆O
Molecular Weight	388.89
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Light yellow to yellow Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD02179211
SMILES	CC([C@@H](NC1=NC(NC2=CC=CC(Cl)=C2)=C3N=CN(C(C)C)C3=N1)CO)C
Target Point	CDK
Passage	Cell Cycle
Background	Purvalanol A is a potent CDK inhibitor.
Biological Activity	Purvalanol A 是一种有效的 CDK 抑制剂，对 cdc2-cyclin B，cdc2-cyclin B，cdk2-cyclin E，cdk4-cyclin D1 和 cdk5-p35 的 IC50 值分别为 4，70，35，850 和 75 nM。[1-3]
IC50	cdc2-cyclin B:4nM;cdk2-cyclin E:35nM;cdk2-cyclin A:70nM;cdk5-p35:75nM [1-3]
Data Literature Source	[1]. Gray NS，et al. Exploiting chemical libraries，structure，and genomics in the search for kinase inhibitors. Science. 1998 Jul 24;281(5376):533-8. [2]. Bain J，et al. The specificities of protein kinase inhibitors: an update. Biochem J. 2003 Apr 1;371(Pt 1):199-204. [3]. Villerbu N，et al. Cellular effects of purvalanol A: a specific inhibitor of cyclin-dependent kinase activities. Int J Cancer. 2002 Feb 20;97(6):761-9.
Unit	Bottle
Specification	5mg 10mg 25mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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