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NMS-P937

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Cat.No：IN1560 Solarbio

CAS：1034616-18-6

Molecular Formula：C₂₄H₂₇F₃N₈O₃

Molecular Weight：532.52

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light yellow to yellow Solid

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Product Information

CAS	1034616-18-6
Name	NMS-P937
Molecular Formula	C₂₄H₂₇F₃N₈O₃
Molecular Weight	532.52
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Light yellow to yellow Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD26793840
SMILES	O=C(C1=NN(CCO)C2=C1CCC3=CN=C(NC4=CC(N5CCN(C)CC5)=CC=C4OC(F)(F)F)N=C23)N
Target Point	Polo-like Kinase (PLK)
Passage	Cell Cycle
Background	NMS-P937 is a selective Polo-like Kinase 1 (PLK1) inhibitor.
Biological Activity	nMS-1286937 是一种有效、高选择性的 PLK1 抑制剂，IC50 值为 2 nM[1]。
IC50	PLK1:2nM;mELK:744nM;CK2:826nM;FLT3:510nM [1]
Data Literature Source	[1]. Beria I，et al. NMS-P937，a 4，5-dihydro-1H-pyrazolo[4，3-h]quinazoline derivative as potent and selective Polo-like kinase 1 inhibitor. Bioorg Med Chem Lett. 2011 May 15;21(10):2969-74. [2]. Valsasina B，et al. NMS-P937，an orally available，specific small-molecule polo-like kinase 1 inhibitor with antitumor activity in solid and hematologic malignancies. Mol Cancer Ther. 2012 Apr;11(4):1006-16. [3]. Casolaro A，et al. The Polo-Like Kinase 1 (PLK1) inhibitor NMS-P937 is effective in a new model of disseminated primary CD56+ acute monoblastic leukaemia. PLoS One. 2013;8(3):e58424.
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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