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Lifitegrast

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Cat.No：IL1720 Solarbio

CAS：1025967-78-5

Molecular Formula：C₂₉H₂₄Cl₂N₂O₇S

Molecular Weight：615.48

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	1025967-78-5
Name	Lifitegrast
Molecular Formula	C₂₉H₂₄Cl₂N₂O₇S
Molecular Weight	615.48
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 813-044-8
MDL	MFCD28502439
SMILES	O=C(O)[C@H](CC1=CC=CC(S(=O)(C)=O)=C1)NC(C2=C(Cl)C3=C(CN(C(C4=CC=C5C=COC5=C4)=O)CC3)C=C2Cl)=O
Target Point	Integrin
Passage	Cytoskeleton
Background	Lifitegrast is a novel integrin antagonist.
Biological Activity	Lifitegrast (SAR 1118) is a potent integrin antagonist. Lifitegrast blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1)， interrupting the T cell-mediated inflammatory cycle. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM. Lifitegrast can be used for researching dry eye disease[1].
Data Literature Source	[1]. Perez VL，et al. Lifitegrast，a Novel Integrin Antagonist for Treatment of Dry Eye Disease. Ocul Surf. 2016 Apr;14(2):207-15. [2]. Sun Y，et al. Corneal inflammation is inhibited by the LFA-1 antagonist，lifitegrast (SAR 1118). J Ocul Pharmacol Ther. 2013 May;29(4):395-402.
Unit	Bottle
Specification	2mg 5mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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