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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > KW-2478CAS：819812-04-9
Molecular Formula：C30H42N2O9
Molecular Weight：574.66
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 819812-04-9 |
| Name | KW-2478 |
| Molecular Formula | C30H42N2O9 |
| Molecular Weight | 574.66 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD21609267 |
| SMILES | O=C(N(CCOC)CCOC)CC1=C(C(C2=CC=C(OCCN3CCOCC3)C(OC)=C2)=O)C(O)=CC(O)=C1CC |
| Target Point | HSP90 |
| Passage | Cell Cycle;Metabolic Enzyme&Protease |
| Background | KW-2478 is a non-Ansamycin HSP90 inhibitor. |
| Biological Activity | KW-2478 是一种 Hsp90α 抑制剂，IC50 值为 3.8 nM，对多种人类血液肿瘤细胞具有抗肿瘤活性[1]。KW-2478还通过主要抑制Cdk9的功能来抑制c-Maf和Cyclin D1基因的转录[1]。 |
| Data Literature Source | [1]. Nakashima T，et al. New molecular and biological mechanism of antitumor activities of KW-2478，a novel nonansamycin heat shock protein 90 inhibitor，in multiple myeloma cells. Clin Cancer Res. 2010 May 15;16(10):2792-802 |
| Unit | Bottle |
| Specification | 2mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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