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GSK-923295

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Cat.No：IG2350 Solarbio

CAS：1088965-37-0

Molecular Formula：C₃₂H₃₈ClN₅O₄

Molecular Weight：592.13

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light yellow to yellow Solid

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Product Information

CAS	1088965-37-0
Name	GSK-923295
Molecular Formula	C₃₂H₃₈ClN₅O₄
Molecular Weight	592.13
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Light yellow to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 256-495-9
MDL	MFCD16038931
SMILES	O=C(N[C@@H](CC1=CC=C(C2=CN3C(C([C@@H](O)C)=CC=C3)=N2)C=C1)CNC(CN(C)C)=O)C4=CC(Cl)=C(C=C4)OC(C)C
Target Point	Kinesin
Passage	Cytoskeleton
Background	GSK923295 is an allosteric inhibitor of the primary specific allosteric inhibitor CENP-E kinesin ATPase.
Biological Activity	GSK-923295 是一种特异性的变构 CENP-E 驱动蛋白 ATPase 活性抑制剂，作用于人类和犬类此酶，Ki 分别为 3.2±0.2 nM 和 1.6±0.1 nM[1-3]。
Data Literature Source	[1]. Wood KW，et al. Antitumor activity of an allosteric inhibitor of centromere-associated protein-E. Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5839-44. [2]. Mayes PA，et al. Mitogen-activated protein kinase (MEK/ERK) inhibition sensitizes cancer cells to centromere-associated protein E (CENP-E) inhibition. Int J Cancer. 2013 Feb 1;132(3):E149-57. [3]. Balamuth NJ，et al. Serial transcriptome analysis and cross-species integration identifies centromere-associated protein E as a novel neuroblastoma target. Cancer Res. 2010 Apr 1;70(7):2749-58
Unit	Bottle
Specification	2mg 5mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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