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CGK-733

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Cat.No：IC3640 Solarbio

CAS：905973-89-9

Molecular Formula：C₂₃H₁₈Cl₃FN₄O₃S

Molecular Weight：555.84

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	905973-89-9
Name	CGK-733
Molecular Formula	C₂₃H₁₈Cl₃FN₄O₃S
Molecular Weight	555.84
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD00004382
SMILES	FC1=CC=C(NC(NC(C(Cl)(Cl)Cl)NC(C(C2=CC=CC=C2)C3=CC=CC=C3)=O)=S)C=C1[N+]([O-])=O
Target Point	ATM/ATR
Passage	DNA Damage/DNA Repair; PI3K/Akt/mTOR
Background	CGK 733 is a potent ATM/ATR selective inhibitor.
Biological Activity	CGK733 是一种有效的 ATM/ATR 抑制剂，用于癌症研究[1-3]。
Data Literature Source	[1]. Wang H，et al. CGK733 enhances multinucleated cell formation and cytotoxicity induced by taxol in Chk1-deficient HBV-positive hepatocellular carcinoma cells. Biochem Biophys Res Commun. 2012 May 25;422(1):103-8. [2]. Alao JP，et al. The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation. Radiat Oncol. 2009 Nov 10;4:51. [3]. Williams TM，et al. Molecular imaging of the ATM kinase activity. Int J Radiat Oncol Biol Phys. 2013 Aug 1;86(5):969-77.
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.

2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.

3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.