{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > CCT-137690CAS：1095382-05-0
Molecular Formula：C26H31BrN8O
Molecular Weight：551.48
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to brown Solid
Qty：
Size：
| CAS | 1095382-05-0 |
| Name | CCT-137690 |
| Molecular Formula | C26H31BrN8O |
| Molecular Weight | 551.48 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to brown Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00070773 |
| SMILES | CC1=CC(CN(CC2)CCN2C3=C4C(NC(C5=CC=C(N6CCN(C)CC6)C=C5)=N4)=NC=C3Br)=NO1 |
| Target Point | Aurora Kinase |
| Passage | Cell Cycle |
| Background | CCT137690 is a highly selective Aurora A, Aurora B and Aurora C inhibitor. |
| Biological Activity | CCT 137690是有效的，有口服活性的Aurora抑制剂，对Aurora A，B，C的 IC50 值分别为15，25 和19 nM[1-2]。 |
| IC50 | Aurora A:15nM;Aurora B:25nM;Aurora C:19nM [1-2] |
| Data Literature Source | [1]. Bavetsias V，et al. Imidazo[4，5-b]pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidate. J Med Chem. 2010 Jul 22;53(14):5213-28. [2]. Faisal A，et al. The aurora kinase inhibitor CCT137690 downregulates MYCN and sensitizes MYCN-amplified neuroblastoma in vivo. Mol Cancer Ther. 2011 Nov;10(11):2115-23. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
