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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > AtuveciclibCAS：1414943-88-6
Molecular Formula：C18H18FN5O2S
Molecular Weight：387.43
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1414943-88-6 |
| Name | Atuveciclib |
| Molecular Formula | C18H18FN5O2S |
| Molecular Weight | 387.43 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD30502894 |
| SMILES | N=S(CC1=CC(NC2=NC(C3=CC=C(F)C=C3OC)=NC=N2)=CC=C1)(C)=O |
| Target Point | CDK9 |
| Passage | Cell Cycle |
| Background | It is a potent and highly selective PTEFb/CDK9 inhibitor. |
| Biological Activity | Atuveciclib (BAY-1143572)是一种有效的、高选择性PTEFb/CDK9抑制剂，对CDK9/CycT的IC50值为13 nM。它对CDK2的IC50是其对CDK9的约100倍。除了CDK家族成员，它还抑制GSK3激酶，对GSK3α和GSK3β的IC50值分别为45 nM和87 nM。[1-2] |
| Data Literature Source | [1] Lücking U，et al. ChemMedChem. 2017，12(21):1776-1793. [2] Wong RWJ，et al. Molecules. 2018，23(5). pii: E1057. |
| Unit | Bottle |
| Specification | 2mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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