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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > 6H-05CAS：2061344-88-3
Molecular Formula：C22H31ClF3N3O4S3
Molecular Weight：590.14
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 2061344-88-3 |
| Name | 6H-05 |
| Molecular Formula | C22H31ClF3N3O4S3 |
| Molecular Weight | 590.14 |
| Solubility | Soluble in Water/DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | O=C(C1CCN(C(CSC2=CC=C(Cl)C=C2)=O)CC1)NCCSSCCN(C)C.O=C(O)C(F)(F)F |
| Target Point | Rho inhibitor;K-Ras |
| Passage | Cell Cycle; GPCR & G Protein |
| Background | 6H-05 is a selective, allosteric inhibitor of K-Ras(G12C). |
| Biological Activity | 6H05是一个致癌K-Ras(G12C)的选择性、变构抑制剂。6H05能够用作合成其它致癌性K-Ras(G12C)抑制剂的中间体。[1-2] |
| Data Literature Source | [1]. Ostrem JM，et al. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 2013 Nov 28;503(7477):548-51. [2]. Lu S，et al. Harnessing allostery: a novel approach to drug discovery. Med Res Rev. 2014 Nov;34(6):1242-85. |
| Unit | Bottle |
| Specification | 2mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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