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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Apoptosis > 10058-F4CAS：403811-55-2
Molecular Formula：C12H11NOS2
Molecular Weight：249.35
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 403811-55-2 |
| Name | 10058-F4 |
| Molecular Formula | C12H11NOS2 |
| Molecular Weight | 249.35 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00758517 |
| SMILES | O=C1NC(S/C1=C/C2=CC=C(CC)C=C2)=S |
| InChIKey | SVXDHPADAXBMFB-JXMROGBWSA-N |
| InChI | InChI=1S/C12H11NOS2/c1-2-8-3-5-9(6-4-8)7-10-11(14)13-12(15)16-10/h3-7H,2H2,1H3,(H,13,14,15)/b10-7+ |
| PubChem CID | 1271002 |
| Target Point | c-Myc |
| Passage | Apoptosis |
| Background | 10058-F4 is a c-Myc inhibitor. |
| Biological Activity | 10058-F4是 c-Myc 抑制剂，其阻止c-Myc-Max二聚化和c-Myc靶基因表达的反式激活。[1-3] |
| Data Literature Source | [1]. Huang MJ， et al. A small-molecule c-Myc inhibitor， 10058-F4， induces cell-cycle arrest， apoptosis， and myeloid differentiation of human acute myeloid leukemia. Exp Hematol. 2006 Nov; 34 (11) :1480-9. [2]. Lin CP， et al. Small-molecule c-Myc inhibitor， 10058-F4， inhibits proliferation， downregulates human telomerase reverse transcriptase and enhances chemosensitivity in human hepatocellular carcinoma cells. Anticancer Drugs. 2007 Feb; 18 (2) :161-70. [3]. Guo J， et al. Efficacy， pharmacokinetics， tisssue distribution， and metabolism of the Myc-Max disruptor， 10058-F4 [Z，E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one， in mice. Cancer Chemother Pharmacol. 2009 Mar; 63 (4) :615-25 |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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