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Kobe0065

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Cat.No：IK0440 Solarbio

CAS：436133-68-5

Molecular Formula：C₁₅H₁₁ClF₃N₅O₄S

Molecular Weight：449.79

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light yellow to yellow Solid

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Product Information

CAS	436133-68-5
Name	Kobe0065
Molecular Formula	C₁₅H₁₁ClF₃N₅O₄S
Molecular Weight	449.79
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Light yellow to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD04109603
SMILES	FC(C1=CC([N+]([O-])=O)=C(NNC(NC2=CC=C(C)C(Cl)=C2)=S)C([N+]([O-])=O)=C1)(F)F
Target Point	Ras
Passage	Cell Cycle; GPCR & G Protein
Background	Kobe0065 is an inhibitor of H-Ras-cRaf1 interaction and can effectively inhibit the binding of H-Ras·GTP to c-Raf-1 RBD.
Biological Activity	Kobe0065 is a novel and effective inhibitor of Ras-Raf interaction， competitively inhibiting the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 46±13 μM.[1-2]
Data Literature Source	[1]. Shima， Fumi， et al. In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proceedings of the National Academy of Sciences of the United States of America (2013)， 110(20)， 8182-8187， [2]. Shima F， et al. Discovery of small-molecule Ras inhibitors that display antitumor activity by interfering with Ras·GTP-effector interaction. Enzymes. 2013;34 Pt. B:1-23
Unit	Bottle
Specification	10mg 25mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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