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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > VolasertibCAS：755038-65-4
Molecular Formula：C34H50N8O3
Molecular Weight：618.83
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Off-white to yellow Solid
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| CAS | 755038-65-4 |
| Name | Volasertib |
| Molecular Formula | C34H50N8O3 |
| Molecular Weight | 618.83 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Off-white to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 813-258-1 |
| MDL | MFCD20926414 |
| SMILES | O=C(C1=CC=C(C(OC)=C1)NC2=NC=C(N(C3=O)C)C(N([C@@H]3CC)C(C)C)=N2)N[C@H]4CC[C@@H](CC4)N5CCN(CC5)CC6CC6 |
| Target Point | Polo-like Kinase (PLK) |
| Passage | Cell Cycle |
| Background | Volasertib is a potent Polo-like kinase 1 (PLK1) inhibitor. |
| Biological Activity | Volasertib 是一种高效的 Polo-like 激酶 1 (PLK1) 抑制剂，IC50 值为 0.87 nM，同时能够抑制 PLK2 和 PLK3，IC50 值分别为 5 和 56 nM。[1-3] |
| Data Literature Source | [1]. Xie FF，et al. Volasertib suppresses tumor growth and potentiates the activity of cisplatin in cervical cancer. Am J Cancer Res. 2015 Nov 15;5(12):3548-59. [2]. Abbou S，et al. Polo-like Kinase Inhibitor Volasertib Exhibits Antitumor Activity and Synergy with Vincristine in Pediatric Malignancies. Anticancer Res. 2016 Feb;36(2):599-609. [3]. Rudolph D，et al. BI 6727，a Polo-like kinase inhibitor with improved pharmacokinetic profile and broad antitumor activity.Clin Cancer Res. 2009 May 1;15(9):3094-102. Epub |
| Unit | Bottle |
| Specification | 2mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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