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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > GSK-461364CAS：929095-18-1
Molecular Formula：C27H28F3N5O2S
Molecular Weight：543.62
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 929095-18-1 |
| Name | GSK-461364 |
| Molecular Formula | C27H28F3N5O2S |
| Molecular Weight | 543.62 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-258-5 |
| SMILES | O=C(C(SC(N1C=NC2=CC=C(C=C12)CN3CCN(CC3)C)=C4)=C4O[C@@H](C5=CC=CC=C5C(F)(F)F)C)N |
| Target Point | Polo-like Kinase (PLK) |
| Passage | Cell Cycle |
| Background | GSK461364 is a selective, reversible, ATP-competitive inhibitor of PLK1. |
| Biological Activity | GSK461364 是选择性，可逆，ATP竞争性的 PLK1 抑制剂，Ki 值为 2.2 nM[1-4]。 |
| Data Literature Source | [1]. Olmos D，et al. Phase I study of GSK461364，a specific and competitive Polo-like kinase 1 inhibitor，in patients with advanced solid malignancies. Clin Cancer Res. 2011 May 15;17(10):3420-30. [2]. Degenhardt Y，et al. Sensitivity of cancer cells to Plk1 inhibitor GSK461364A is associated with loss of p53 function and chromosome instability. Mol Cancer Ther. 2010 Jul;9(7):2079-89 [3]. Gilmartin AG，et al. Distinct concentration-dependent effects of the polo-like kinase 1-specific inhibitor GSK461364A，including differential effect on apoptosis. Cancer Res. 2009 Sep 1;69(17):6969-77. [4]. Chou YS，et al. Cytotoxic mechanism of PLK1 inhibitor GSK461364 against osteosarcoma: Mitotic arrest，apoptosis，cellular senescence，and synergistic effect with paclitaxel. Int J Oncol. 2016 Mar;48(3):1187-94. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
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2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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