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AMG-900

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Cat.No：IA3780 Solarbio

CAS：945595-80-2

Molecular Formula：C₂₈H₂₁N₇OS

Molecular Weight：503.58

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light yellow to yellow Solid

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Product Information

CAS	945595-80-2
Name	AMG-900
Molecular Formula	C₂₈H₂₁N₇OS
Molecular Weight	503.58
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Light yellow to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD18633194
SMILES	CC1=CSC(C2=NN=C(C3=C2C=CC=C3)NC4=CC=C(C=C4)OC5=C(C=CC=N5)C6=CC=NC(N)=N6)=C1
Target Point	Aurora Kinase inhibitor
Passage	Cell Cycle
Background	AMG 900 is a potent and selective pan-Aurora kinase inhibitor.
Biological Activity	AMG 900 是一种有效的选择性的 pan-Aurora 激酶抑制剂，作用于 Aurora A，B 和 C，IC50 分别为 5 nM，4 nM 和 1 nM[1-3]。
IC50	Aurora A:5nM;Aurora B:4nM;Aurora C:1nM [1-3]
Data Literature Source	[1]. Payton M，et al. Preclinical evaluation of AMG 900，a novel potent and highly selective pan-aurora kinase inhibitor with activity in taxane-resistant tumor cell lines. Cancer Res，2010，70(23)，9846-9854. [2]. Juan G，et al. AMG 900，a potent inhibitor of aurora kinases causes pharmacodynamic changes in p-Histone H3 immunoreactivity in human tumor xenografts and proliferating mouse tissues. J Transl Med. 2014 Nov 4;12:307. [3]. Huang L，et al. In vitro and in vivo pharmacokinetic characterizations of AMG 900，an orally bioavailable small molecule inhibitor of aurora kinases. Xenobiotica. 2011 May;41(5):400-8.
Unit	Bottle
Specification	5mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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