Your Position: Home > Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Autophagy > LRRK2-IN-1

LRRK2-IN-1

Manual Download

Cat.No：IL1500 Solarbio

CAS：1234480-84-2

Molecular Formula：C₃₁H₃₈N₈O₃

Molecular Weight：570.69

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light yellow to yellow Solid

Qty：

Size：

Add to cart

Product Information Experimental Images Related Products Related Paper Technical Q&A

Product Information

CAS	1234480-84-2
Name	LRRK2-IN-1
Molecular Formula	C₃₁H₃₈N₈O₃
Molecular Weight	570.69
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Light yellow to yellow Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD22683805
SMILES	O=C(C1=CC(OC)=C(NC2=NC=C3C(N(C4=C(C(N3C)=O)C=CC=C4)C)=N2)C=C1)N5CCC(CC5)N6CCN(CC6)C
Target Point	LRRK2
Passage	Autophagy
Background	LRRK2-IN-1 is a potent and selective LRRK2 inhibitor.
Biological Activity	LRRK2-IN-1 是一种有效的, 选择性的 LRRK2 抑制剂, 作用于 LRRK2 (G2019S) 和 LRRK2 (WT) , IC50 值分别为 6 nM 和 13 nM[1-4]。
IC50	IC50: 13nM (WT) ， 6nM (G2019S) [1-4]
Data Literature Source	[1]. Hermanson SB， et al. Screening for Novel LRRK2 Inhibitors Using a High-Throughput TR-FRET Cellular Assay for LRRK2 Ser935 Phosphorylation.PLoS One. 2012; 7 (8) :e43580. Epub 2012 Aug 28. [2]. Deng， Xianming.， et al. Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2. Nature Chemical Biology (2011) ， 7 (4) ， 203-205. [3]. Koshibu K， et al. Alternative to LRRK2-IN-1 for Pharmacological Studies of Parkinson's Disease. Pharmacology. 2015; 96 (5-6) :240-7. [4]. Weygant N， et al. Small molecule kinase inhibitor LRRK2-IN-1 demonstrates potent activity against colorectal and pancreatic cancer through inhibition of doublecortin-like kinase 1. Mol Cancer. 2014 May 6; 13:103
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

Note：

1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.

2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.

3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.