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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Autophagy > GNE-7915CAS：1351761-44-8
Molecular Formula：C19H21F4N5O3
Molecular Weight：443.4
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Off-white to yellow Solid
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| CAS | 1351761-44-8 |
| Name | GNE-7915 |
| Molecular Formula | C19H21F4N5O3 |
| Molecular Weight | 443.4 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Off-white to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD25977005 |
| SMILES | CCNC1=NC(NC2=C(OC)C=C(C(N3CCOCC3)=O)C(F)=C2)=NC=C1C(F)(F)F |
| Target Point | LRRK2 |
| Passage | Autophagy |
| Background | It is a potent and selective LRRK2 inhibitor. |
| Biological Activity | GNE-7915是高效选择性，可渗透大脑的LRRK2抑制剂，IC50值为9 nM。[1-2] |
| Data Literature Source | [1]. Kavanagh ME，et al. The development of CNS-active LRRK2 inhibitors using property-directed optimisation. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3690-6. [2]. Estrada AA，et al. Discovery of highly potent，selective，and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. J Med Chem. 2012 Nov 26;55(22):9416-33 |
| Unit | Bottle |
| Specification | 5mg 10mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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