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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Autophagy > ROC-325CAS：1859141-26-6
Molecular Formula：C28H27ClN4OS
Molecular Weight：503.06
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 1859141-26-6 |
| Name | ROC-325 |
| Molecular Formula | C28H27ClN4OS |
| Molecular Weight | 503.06 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD31619252 |
| SMILES | O=C1C2=C(SC3=C1C=CC=C3)C(C)=CC=C2NCCN(CCNC4=CC=NC5=CC(Cl)=CC=C45)C |
| Target Point | Autophagy |
| Passage | Autophagy |
| Background | ROC-325 is a novel, potent, orally bioactive autophagy inhibitor with potent anticancer activity. |
| Biological Activity | ROC-325是一种新型的，有效的，具有口服生物活性的自噬抑制剂，具有有效的抗癌活性。与现有的自噬抑制剂羟氯喹（HCQ）相比，ROC-325在具有不同遗传背景的12种不同癌细胞系中表现出优异的体外抗癌作用。ROC-325以ATG5/7依赖的方式拮抗RCC的生长和存活，诱导细胞凋亡，并表现出良好的选择性。[1] |
| Data Literature Source | [1]Carew JS，Nawrocki ST. Drain the lysosome: Development of the novel orally available autophagy inhibitor ROC-325. Autophagy. 2017 Apr 3;13(4):765-766. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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