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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > Tenovin-6CAS：1011557-82-6
Molecular Formula：C25H34N4O2S
Molecular Weight：454.63
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1011557-82-6 |
| Name | Tenovin-6 |
| Molecular Formula | C25H34N4O2S |
| Molecular Weight | 454.63 |
| Solubility | Soluble in Water/DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-256-5 |
| MDL | MFCD11976906 |
| SMILES | O=C(NC(NC1=CC=C(NC(CCCCN(C)C)=O)C=C1)=S)C2=CC=C(C(C)(C)C)C=C2 |
| Target Point | Sirtuin;p53;dihydroorotate dehydrogenase (DHODH) |
| Passage | Cell Cycle;DNA Damage/DNA Repair; Epigenetics;Apoptosis;Metabolic Enzyme&Protease |
| Background | Tenovin-6 is a small molecule activator of p53 transcriptional activity and can inhibit dihydroorotate dehydrogenase (DHODH). Tenovin-6 is also an inhibitor of SirT1 and SirT2. |
| Biological Activity | Tenovin-6 是水溶的 SIRT1、SIRT2 抑制剂，p53 的激活剂，同时能抑制 HDAC8 的活性，对 SirT1 peptide deacetylase，SirT2 和 SirT3 的 IC50 值分别为 21 μM，10 μM 和 67 μM。[1-4] |
| IC50 | SIRT2:10μM;SIRT1:21μM;SIRT3:67μM [1-4] |
| Data Literature Source | [1]. Lain S，et al. Discovery，in vivo activity，and mechanism of action of a small-molecule p53 activator. Cancer Cell. 2008 May;13(5):454-63. [2]. Yuan H，et al. Tenovin-6 impairs autophagy by inhibiting autophagic flux. Cell Death Dis. 2017 Feb 9;8(2):e2608. [3]. Yuan H，et al. Tenovin-6 inhibits proliferation and survival of diffuse large B-cell lymphoma cells by blocking autophagy. Oncotarget. 2017 Feb 28;8(9):14912-14924. [4]. Dai W，et al. Class III-specific HDAC inhibitor Tenovin-6 induces apoptosis，suppresses migration and eliminates cancer stem cells in uveal melanoma. Sci Rep. 2016 Mar 4;6:22622 |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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