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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Autophagy > DaurisolineCAS：70553-76-3
Molecular Formula：C37H42N2O6
Molecular Weight：610.75
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 70553-76-3 |
| Name | Daurisoline |
| Molecular Formula | C37H42N2O6 |
| Molecular Weight | 610.75 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 683-239-9 |
| MDL | MFCD00221740 |
| SMILES | OC1=CC2=C(C=C1OC)CCN(C)[C@@H]2CC3=CC=C(O)C(OC4=CC=C(C[C@H]5N(C)CCC6=C5C=C(OC)C(OC)=C6)C=C4)=C3 |
| InChIKey | BURJAQFYNVMZDV-FIRIVFDPSA-N |
| InChI | InChI=1S/C37H42N2O6/c1-38-15-13-26-20-36(43-4)37(44-5)22-29(26)30(38)16-23-6-9-27(10-7-23)45-35-18-24(8-11-32(35)40)17-31-28-21-33(41)34(42-3)19-25(28)12-14-39(31)2/h6-11,18-22,30-31,40-41H,12-17H2,1-5H3/t30-,31-/m1/s1 |
| PubChem CID | 51106 |
| Target Point | Autophagy |
| Passage | Autophagy |
| Background | Daurisoline is a hERG inhibitor and an autophagy inhibitor. |
| Biological Activity | Daurisoline 是一个 hERG 抑制剂，也是一种自噬抑制剂[1-3]。 |
| Data Literature Source | [1]. Liu Q，et al. Effect of daurisoline on HERG channel electrophysiological function and protein expression. J Nat Prod. 2012 Sep 28;75(9):1539-45. [2]. Wu MY，et al. Natural autophagy blockers，dauricine (DAC) and daurisoline (DAS)，sensitize cancer cells tocamptothecin-induced toxicity. Oncotarget. 2017 Sep 8;8(44):77673-77684. [3]. Shi SJ，et al. Pharmacokinetic-pharmacodynamic modeling of daurisoline and dauricine in beagle dogs. Acta Pharmacol Sin. 2003 Oct;24(10):1011-5 |
| Unit | Bottle |
| Specification | 5mg 10mg 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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