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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Apoptosis > IdasanutlinCAS：1229705-06-9
Molecular Formula：C31H29Cl2F2N3O4
Molecular Weight：616.48
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1229705-06-9 |
| Name | Idasanutlin |
| Molecular Formula | C31H29Cl2F2N3O4 |
| Molecular Weight | 616.48 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD26142931 |
| SMILES | O=C(O)C1=CC(OC)=C(NC([C@H]2[C@H](C3=C(F)C(Cl)=CC=C3)[C@](C4=CC=C(Cl)C=C4F)(C#N)[C@H](CC(C)(C)C)N2)=O)C=C1 |
| Target Point | MDM-2 |
| Passage | Apoptosis |
| Background | Idasanutlin is a potent and selective MDM2 antagonist capable of inhibiting p53-MDM2 binding. |
| Biological Activity | Idasanutlin 是一种有效，选择性的 MDM2 拮抗剂，能够抑制 p53-MDM2 的结合，IC50 值为 6 nM。[1-2] |
| IC50 | 6nM(p53-MDM2)[1] |
| Data Literature Source | [1]. Ding Q，et al. Discovery of RG7388，a potent and selective p53-MDM2 inhibitor in clinical development. J Med Chem. 2013 Jul 25;56(14):5979-83. [2]. Higgins B，et al. Preclinical optimization of MDM2 antagonist scheduling for cancer treatment by using a model-based approach. Clin Cancer Res. 2014，20(14)，3742-3752 |
| Unit | Bottle |
| Specification | 2mg 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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