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My CartCAS：1235034-55-5
Molecular Formula：C35H32FN5O4S2
Molecular Weight：669.79
Storage：Powder:-20℃，1 year;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to brown Solid
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| CAS | 1235034-55-5 |
| Name | A-1155463 |
| Molecular Formula | C35H32FN5O4S2 |
| Molecular Weight | 669.79 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to brown Solid |
| Storage | Powder:-20℃，1 year;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD29924714 |
| SMILES | O=C(C1=C(CCCOC2=CC=C(C#CCN(C)C)C=C2F)SC(N3CC4=C(C=CC=C4C(NC5=NC6=CC=CC=C6S5)=O)CC3)=N1)O |
| Target Point | Bcl-xL |
| Passage | Apoptosis |
| Background | A-1155463 is a highly potent and selective BCL-XL inhibitor. |
| Biological Activity | A-1155463是一种高度有效、选择性的BCL-XL抑制剂。其对BCL-XL的亲和力属于皮摩尔级别，对BCL-2、BCL-W（Ki=19 nM）、MCL-1（Ki>440 nM）的结合比对BCL-XL弱1000倍以上。[1-3] |
| Data Literature Source | [1] Tao ZF，et al. ACS Med Chem Lett. 2014，5(10):1088-93. [2] Leverson JD，et al. Sci Transl Med. 2015，7(279):279ra40. [3] Haichao Zhang，et al. Molecular Cancer. 2015，14(1):1-9. |
| Unit | Bottle |
| Specification | 2mg 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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