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Venetoclax

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Cat.No：IV0650 Solarbio

CAS：1257044-40-8

Molecular Formula：C₄₅H₅₀ClN₇O₇S

Molecular Weight：868.44

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥97%

Appearance：Light yellow to yellow Solid

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Product Information

CAS	1257044-40-8
Name	Venetoclax
Molecular Formula	C₄₅H₅₀ClN₇O₇S
Molecular Weight	868.44
Solubility	Soluble in DMSO
Purity	≥97%
Appearance	Light yellow to yellow Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 820-130-9
MDL	MFCD23160052
SMILES	O=C(NS(=O)(C1=CC=C(NCC2CCOCC2)C([N+]([O-])=O)=C1)=O)C3=CC=C(N4CCN(CC5=C(C6=CC=C(Cl)C=C6)CC(C)(C)CC5)CC4)C=C3OC7=CN=C(NC=C8)C8=C7
Target Point	Bcl-2
Passage	Apoptosis
Background	Venetoclax is a potent and selective Bcl-2 inhibitor.
Biological Activity	Venetoclax (GDC-0199; ABT-199) 是一种高效，有选择性和口服活性的 Bcl-2 抑制剂，Ki 小于0.01 nM。[1-3]
Data Literature Source	[1]. Souers AJ，et al. ABT-199，a potent and selective BCL-2 inhibitor，achieves antitumor activity while sparing platelets. Nat Med. 2013 Feb;19(2):202-8. [2]. Peirs S，et al. ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia. Blood. 2014 Dec 11;124(25):3738-47. [3]. Bi C，et al. Inhibition of 4EBP phosphorylation mediates the cytotoxic effect of mechanistic target of rapamycin kinase inhibitors in aggressive B-cell lymphomas. Haematologica. 2017 Apr;102(4):755-764.
Unit	Bottle
Specification	2mg 5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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