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Birinapant

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Cat.No：IB1240 Solarbio

CAS：1260251-31-7

Molecular Formula：C₄₂H₅₆F₂N₈O₆

Molecular Weight：806.94

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Off-white to yellow Solid

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Product Information

CAS	1260251-31-7
Name	Birinapant
Molecular Formula	C₄₂H₅₆F₂N₈O₆
Molecular Weight	806.94
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Off-white to yellow Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD25976869
SMILES	FC1=CC2=C(C=C1)C(C[C@H]3N(C([C@@H](NC([C@@H](NC)C)=O)CC)=O)C[C@@H](O)C3)=C(C(N4)=C(C[C@H]5N(C([C@@H](NC([C@@H](NC)C)=O)CC)=O)C[C@@H](O)C5)C6=C4C=C(F)C=C6)N2
Target Point	Apoptosis;IAP
Passage	Apoptosis
Background	Birinapant is a potent antagonist of XIAP and cIAP1.
Biological Activity	Birinapant是一种二价Smac模拟物，是 XIAP 和 cIAP1 的强效拮抗剂，Kd 值分别为45 nM和小于1 nM[1-3]。
Data Literature Source	[1]. Allensworth JL，et al. Smac mimetic Birinapant induces apoptosis and enhances TRAIL potency in inflammatory breast cancer cells in an IAP-dependent and TNF-α-independent mechanism. Breast Cancer Res Treat. 2013 Jan;137(2):359-71. [2]. Krepler C，et al. The novel SMAC mimetic birinapant exhibits potent activity against human melanoma cells. Clin Cancer Res. 2013 Apr 1;19(7):1784-94. [3]. Nguyen QD，et al. Temporal and spatial evolution of therapy-induced tumor apoptosis detected by caspase-3-selective molecular imaging. Clin Cancer Res. 2013 Jul 15;19(14):3914-24.
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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