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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > ER Stress > GSK2656157CAS：1337532-29-2
Molecular Formula：C23H21FN6O
Molecular Weight：416.45
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to brown Solid
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| CAS | 1337532-29-2 |
| Name | GSK2656157 |
| Molecular Formula | C23H21FN6O |
| Molecular Weight | 416.45 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to brown Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD27997885 |
| SMILES | CC1=CC=CC(CC(N2CCC3=C2C=CC(C4=CN(C)C5=NC=NC(N)=C54)=C3F)=O)=N1 |
| Target Point | PERK |
| Passage | ER Stress;Cell Cycle |
| Background | GSK2656157 is a selective, ATP-competitive inhibitor of PERK. |
| Biological Activity | GSK2656157 是选择性，ATP竞争性的 PERK 抑制剂，IC50 值为 0.9 nM[1-4]。 |
| Data Literature Source | [1]. Atkins C，et al. Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity. Cancer Res. 2013 Mar 15;73(6):1993-2002. [2]. Krishnamoorthy J，et al. Evidence for eIF2α phosphorylation-independent effects of GSK2656157，a novel catalytic inhibitor of PERK with clinical implications. Cell Cycle. 2014 Mar 1;13(5):801-6. [3]. Ando T，et al. GSK2656157，a PERK inhibitor，reduced LPS-induced IL-1β production through inhibiting Caspase 1 activation in macrophage-like J774.1 cells. Immunopharmacol Immunotoxicol. 2016 Aug;38(4):298-302. [4]. Zhao Q，et al. Thioredoxin-interacting protein links endoplasmic reticulum stress to inflammatory brain injury and apoptosis after subarachnoid haemorrhage. J Neuroinflammation. 2017 May 11;14(1):104. |
| Unit | Bottle |
| Specification | 5mg 10mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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