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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Apoptosis > BH3I-1CAS：300817-68-9
Molecular Formula：C15H14BrNS2O3
Molecular Weight：400.31
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥97%
Appearance：Light yellow to yellow Solid
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| CAS | 300817-68-9 |
| Name | BH3I-1 |
| Molecular Formula | C15H14BrNS2O3 |
| Molecular Weight | 400.31 |
| Solubility | Soluble in DMSO |
| Purity | ≥97% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD03453544 |
| SMILES | O=C(O)C(C(C)C)N(C/1=O)C(SC1=C\C2=CC=C(Br)C=C2)=S |
| Target Point | Bcl-2 Family;MDM-2/p53 |
| Passage | Apoptosis |
| Background | BH3I-1 is a Bcl-XL-BH3 domain interaction inhibitor. It is a selective inhibitor of Bcl-2 family proteins. |
| Biological Activity | BH3I-1 is a Bcl-2 family antagonist, which inhibits the binding of the Bak BH3 peptide to Bcl-xL with a Ki of 2.4±0.2 μM in FP assay. BH3I-1 has a Kd of 5.3 μM against the p53/MDM2 pair.[1-3] |
| Data Literature Source | [1]. Wang L，et al. Development of dimeric modulators for anti-apoptotic Bcl-2 proteins. Bioorg Med Chem Lett. 2008 Jan 1;18(1):236-40. [2]. Degterev A，et al. Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL. Nat Cell Biol. 2001 Feb;3(2):173-82. [3]. Porter JR，et al. Profiling small molecule inhibitors against helix-receptor interactions: the Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2. Chem Commun (Camb). 2010 Nov 14;46(42):8020-2. |
| Unit | Bottle |
| Specification | 10mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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