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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Apoptosis > Nutlin-3bCAS：675576-97-3
Molecular Formula：C30H30Cl2N4O4
Molecular Weight：581.49
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Off-white to yellow Solid
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| CAS | 675576-97-3 |
| Name | Nutlin-3b |
| Molecular Formula | C30H30Cl2N4O4 |
| Molecular Weight | 581.49 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Off-white to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | O=C1NCCN(C(N2[C@@H](C3=CC=C(Cl)C=C3)[C@@H](C4=CC=C(Cl)C=C4)N=C2C5=CC=C(OC)C=C5OC(C)C)=O)C1 |
| Target Point | MDM-2/p53 |
| Passage | Apoptosis |
| Background | Nutlin-3b is an MDM2/p53 inhibitor. |
| Biological Activity | Nutlin-3b是MDM2/p53抑制剂, IC50为13.6 μM[1-5]。 |
| IC50 | IC50: 13.6μM (MDM2/p53) [1-5] |
| Data Literature Source | [1]. Ye F， Lattif AA， Xie J， Weinberg A， Gao S.Nutlin-3 induces apoptosis， disrupts viral latency and inhibits expression of angiopoietin-2 in Kaposi sarcoma tumor cells.Cell Cycle. 2012 Apr 1; 11 (7) :1393-9. Epub 2012 Apr 1. [2]. Shin JS， Ha JH， He F， Muto Y， Ryu KS， Yoon HS， Kang S， Park SG， Park BC， Choi SU， Chi SW.Structural insights into the dual-targeting mechanism of Nutlin-3.Biochem Biophys Res Commun. 2012 Mar 30; 420 (1) :48-53. [3]. Gasparini C， Tommasini A， Zauli G.The MDM2 inhibitor Nutlin-3 modulates dendritic cell-induced T cell proliferation.Hum Immunol. 2012 Apr; 73 (4) :342-5. [4]. Ma T， Yamada S， Ichwan SJ， Iseki S， Ohtani K， Otsu M， Ikeda MA.Inability of p53-reactivating compounds Nutlin-3 and RITA to overcome p53 resistance in tumor cells deficient in p53Ser46 phosphorylation.Biochem Biophys Res Commun. 2012 Jan 20; 417 (3) :931-7. [5]. Vatsyayan R， Singhal J， Nagaprashantha LD， Awasthi S， Singhal SS.Nutlin-3 enhances sorafenib efficacy in renal cell carcinoma.Mol Carcinog. 2011 Oct 17. doi: 10.1002/mc.20875 |
| Unit | Bottle |
| Specification | 2mg 5mg 10mM*1mL in DMSO 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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