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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Stem Cells > LY-411575CAS：209984-57-6
Molecular Formula：C26H23F2N3O4
Molecular Weight：479.48
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 209984-57-6 |
| Name | LY-411575 |
| Molecular Formula | C26H23F2N3O4 |
| Molecular Weight | 479.48 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD09832551 |
| SMILES | C[C@@H](C(=O)N[C@H]1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)[C@H](C4=CC(=CC(=C4)F)F)O |
| Target Point | Apoptosis;Notch; -secretase |
| Passage | Apoptosis;Stem Cells;Neuronal Signaling;Stem Cells |
| Background | LY411575, a potent γ-secretase inhibitor, also inhibits Notch fission. |
| Biological Activity | LY-411575 是高效的 γ-secretase 抑制剂，能够抑制 Aβ40 蛋白的产生，其 IC50 值为 0.078 nM/0.082 nM（基于膜/细胞），同时抑制 Notch 分裂，IC50 值为 0.39 nM。[1-5] |
| Data Literature Source | [1]. Wong GT，et al. Chronic treatment with the gamma-secretase inhibitor LY-411，575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation. J Biol Chem. 2004 Mar 26;279(13):12876-82. [2]. Curry CL，et al. Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells. Oncogene. 2005 Sep 22;24(42):6333-44. [3]. Hyde LA，et al. Studies to investigate the in vivo therapeutic window of the gamma-secretase inhibitor N2-[(2S)-2-(3，5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6，7-dihydro-5H-dibenzo[b，d]azepin-7-yl]-L-alaninamide (LY411，575) in the CRND8 mouse. J Pharmacol Exp Ther. 2006 Dec;319(3):1133-43. [4]. Otoguro T，et al. Inhibitory effect of presenilin inhibitor LY411575 on maturation of hepatitis C virus core protein，production of the viral particle and expression of host proteins involved in pathogenicity. Microbiol Immunol. 2016 Nov;60(11):740-753 [5]. Zhang J，et al. Notch signaling modulates proliferative vitreoretinopathy via regulating retinal pigment epithelial-to-mesenchymal transition. Histochem Cell Biol. 2017 Mar;147(3):367-375. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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