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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Stem Cells > DibenzazepineCAS：209984-56-5
Molecular Formula：C26H23F2N3O3
Molecular Weight：463.48
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 209984-56-5 |
| Name | Dibenzazepine |
| Molecular Formula | C26H23F2N3O3 |
| Molecular Weight | 463.48 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD12828734 |
| SMILES | C[C@@H](C(=O)N[C@H]1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)CC4=CC(=CC(=C4)F)F |
| Target Point | Notch;-secretase |
| Passage | Stem Cells;Neuronal Signaling |
| Background | Dibenzazepine is a γ-secretase inhibitor that acts on APPL and Notch cleavage. |
| Biological Activity | YO-01027 (Dibenzazepine;DBZ)是高效的γ-分泌酶抑制剂，裂解Notch和APPL的IC50分别为2.92±0.22和 2.64±0.30 nM。[1-4] |
| IC50 | 2.92±0.22(Notch)，2.64±0.30(APPL)nM[1] |
| Data Literature Source | [1]. Groth C，et al. Pharmacological analysis of Drosophila melanogaster gamma-secretase with respect to differential proteolysis of Notch and APP. Mol Pharmacol. 2010 Apr;77(4):567-74. [2]. Fuwa H，et al. Divergent synthesis of multifunctional molecular probes to elucidate the enzyme specificity of dipeptidic gamma-secretase inhibitors. ACS Chem Biol. 2007 Jun 15;2(6):408-18. [3]. Zheng YH，et al. Notch γ-secretase inhibitor dibenzazepine attenuates angiotensin II-induced abdominal aortic aneurysm in ApoE knockout mice by multiple mechanisms. PLoS One. 2013 Dec 16;8(12):e83310. [4]. Xiao Z，et al. The Notch γ-secretase inhibitor ameliorates kidney fibrosis via inhibition of TGF-β/Smad2/3 signaling pathway activation. Int J Biochem Cell Biol. 2014 Oct;55:65-71 |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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