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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > GSK 650394CAS：890842-28-1
Molecular Formula：C25H22N2O2
Molecular Weight：382.45
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Off-white to yellow Solid
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| CAS | 890842-28-1 |
| Name | GSK 650394 |
| Molecular Formula | C25H22N2O2 |
| Molecular Weight | 382.45 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Off-white to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD12828779 |
| SMILES | C1CCC(C1)C2=C(C=CC(=C2)C3=CNC4=C3C=C(C=N4)C5=CC=CC=C5)C(=O)O |
| Target Point | SGK |
| Passage | Metabolic Enzyme&Protease |
| Background | GSK650394 is a serum and glucocorticoid-regulated kinase-1 inhibitor. |
| Biological Activity | GSK 650394 is a novel SGK inhibitor with IC50 of 62 nM and 103 nM for SGK1 and SGK2 in the SPA assay respectively. GSK 650394 also inhibits influenza virus replication.[1-5] |
| Data Literature Source | [1]. Sherk AB， et al. Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic. Cancer Res. 2008 Sep 15;68(18):7475-83. [2]. Mansley MK， et al. Effects of nominally selective inhibitors of the kinases PI3K， SGK1 and PKB on the insulin-dependent control of epithelial Na+ absorption. Br J Pharmacol. 2010 Oct;161(3):571-88. [3]. Peng HY， et al. Spinal SGK1/GRASP-1/Rab4 is involved in complete Freunds adjuvant-induced inflammatory pain via regulating dorsal horn GluR1-containing AMPA receptor trafficking in rats. Pain. 2012 Dec;153(12):2380-92. [4]. Peng HY， et al. Spinal serum-inducible and glucocorticoid-inducible kinase 1 mediates neuropathic pain via kalirin and downstream PSD-95-dependent NR2B phosphorylation in rats. J Neurosci. 2013 Mar 20;33(12):5227-40. [5]. Alamares-Sapuay JG， et al. Serum- and glucocorticoid-regulated kinase 1 is required for nuclear export of the ribonucleoprotein of influenza A virus. J Virol. 2013 May;87(10):6020-6. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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