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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > DefactinibCAS：1073154-85-4
Molecular Formula：C20H21F3N8O3S
Molecular Weight：510.49
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1073154-85-4 |
| Name | Defactinib |
| Molecular Formula | C20H21F3N8O3S |
| Molecular Weight | 510.49 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD25977806 |
| SMILES | CNC(=O)C1=CC=C(C=C1)NC2=NC=C(C(=N2)NCC3=NC=CN=C3N(C)S(=O)(=O)C)C(F)(F)F |
| Target Point | FAK |
| Passage | Angiogenesis; Protein Tyrosine Kinase/RTK |
| Background | Defactinib is a selective FAK inhibitor. Phase 2. |
| Biological Activity | Defactinib 是一种新型 FAK 抑制剂，抑制 FAK 在 Tyr397 位点磷酸化，这种作用具有时间和剂量依赖性。[1] |
| Data Literature Source | [1]. Kang Y，et al. Role of focal adhesion kinase in regulating YB-1-mediated paclitaxel resistance in ovarian cancer. J Natl Cancer Inst. 2013 Oct 2;105(19):1485-95 |
| Unit | Bottle |
| Specification | 5mg 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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