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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > HIF > BAY87-2243CAS：1227158-85-1
Molecular Formula：C26H26F3N7O2
Molecular Weight：525.53
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1227158-85-1 |
| Name | BAY87-2243 |
| Molecular Formula | C26H26F3N7O2 |
| Molecular Weight | 525.53 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | FC(F)(F)OC1=CC=C(C2=NOC(C3=NN(CC4=CC(N5CCN(C6CC6)CC5)=NC=C4)C(C)=C3)=N2)C=C1 |
| Target Point | HIF/HIF Prolyl-Hydroxylase |
| Passage | HIF |
| Background | BAY 87-2243 is a potent and selective HIF-1 inhibitor. |
| Biological Activity | BAY 87-2243 是一种有效的选择性的 缺氧诱导因子-1 (HIF-1) 抑制剂[1-2]。 |
| Data Literature Source | [1]. Ellinghaus P，et al. BAY 87-2243，a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I. Cancer Med. 2013 Oct;2(5):611-24. [2]. Helbig L，et al. BAY 87-2243，a novel inhibitor of hypoxia-induced gene activation，improves local tumor control after fractionated irradiation in a schedule-dependent manner in head and neck human xenografts. Radiat Oncol. 2014 Sep 19;9:207. |
| Unit | Bottle |
| Specification | 5mg 10mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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