{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Protein Tyrosine Kinase/PTK > AsciminibCAS：1492952-76-7
Molecular Formula：C20H18ClF2N5O3
Molecular Weight：449.84
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 1492952-76-7 |
| Name | Asciminib |
| Molecular Formula | C20H18ClF2N5O3 |
| Molecular Weight | 449.84 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD31560488 |
| SMILES | O=C(C1=CC(C2=NNC=C2)=C(N3C[C@H](O)CC3)N=C1)NC4=CC=C(OC(F)(Cl)F)C=C4 |
| Target Point | Bcr-Abl |
| Passage | Protein Tyrosine Kinase/RTK |
| Background | Asciminib is a potent and selective allosteric inhibitor of ABL1. |
| Biological Activity | Asciminib (ABL001)是一种有效的、选择性的ABL1变构抑制剂，Kd值为0.5-0.8 nM，与ABL1的十四酰口袋结合。[1-3] |
| Data Literature Source | [1] Andrew Wylie，et al. Blood. 2014，124:398. [2] William Sellers. AACR; Clin Cancer Res. 2017，23(1_Suppl):Abstract nr IA01. [3] Andrew A. Wylie，et al. Nature. 2017，543: 733-737. |
| Unit | Bottle |
| Specification | 5mg 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
