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Nazartinib

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Cat.No：IN0920 Solarbio

CAS：1508250-71-2

Molecular Formula：C₂₆H₃₁ClN₆O₂

Molecular Weight：495.02

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Off-white to yellow Solid

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Product Information

CAS	1508250-71-2
Name	Nazartinib
Molecular Formula	C₂₆H₃₁ClN₆O₂
Molecular Weight	495.02
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Off-white to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD28963918
SMILES	O=C(C1=CC(C)=NC=C1)NC2=NC3=CC=CC(Cl)=C3N2[C@H]4CN(C(/C=C/CN(C)C)=O)CCCC4
Target Point	EGFR
Passage	Angiogenesis;Protein Tyrosine Kinase/RTK; JAK/STAT Signaling
Background	It is a novel, covalent/irreversible mutant-selective EGFR inhibitor.
Biological Activity	Nazartinib (EGF816) is a covalent mutant-selective EGFR inhibitor， with Ki and Kinact of 31 nM and 0.222 min?1 on EGFR(L858R/790M) mutant， respectively[1-2]
Data Literature Source	[1]. Lelais G， et al. Discovery of (R，E)-N-(7-Chloro-1-(1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide (EGF816)， a Novel， Potent， and WT Sparing Covalent Inhibitor of Oncogenic (L858R， ex19del) and Resistant (T79 [2]. Jia Y， et al. EGF816 Exerts Anticancer Effects in Non-Small Cell Lung Cancer by Irreversibly and Selectively Targeting Primary and Acquired Activating Mutations in the EGF Receptor. Cancer Res. 2016 Mar 15;76(6):1591-602
Unit	Bottle
Specification	5mg 10mg 25mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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