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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > PRN1371CAS：1802929-43-6
Molecular Formula：C26H30Cl2N6O4
Molecular Weight：561.46
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1802929-43-6 |
| Name | PRN1371 |
| Molecular Formula | C26H30Cl2N6O4 |
| Molecular Weight | 561.46 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | O=C1C(C2=C(Cl)C(OC)=CC(OC)=C2Cl)=CC3=CN=C(NC)N=C3N1CCCN4CCN(C(C=C)=O)CC4 |
| Target Point | FGFR |
| Passage | Angiogenesis; Protein Tyrosine Kinase/RTK |
| Background | PRN1371 is an irreversible covalent inhibitor of FGFR1-4. |
| Biological Activity | PRN1371 is a highly selective and potent FGFR1-4 and CSF1R inhibitor with IC50s of 0.6， 1.3， 4.1， 19.3 and 8.1 nM for FGFR1， FGFR2， FGFR3， FGFR4 and CSF1R， respectively.[1] |
| Data Literature Source | [1]. Brameld KA， et al. Discovery of the Irreversible Covalent FGFR Inhibitor 8-(3-(4-Acryloylpiperazin-1-yl)propyl)-6-(2，6-dichloro-3，5-dimethoxyphenyl)-2-(methylamino)pyrido[2，3-d]pyrimidin-7(8H)-one (PRN1371) for the Treatment of Solid Tumors. J Med Chem. 2 |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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