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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > HIF > PX-478 2HClCAS：685898-44-6
Molecular Formula：C13H20Cl4N2O3
Molecular Weight：394.12
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Yellow to brown Solid
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| CAS | 685898-44-6 |
| Name | PX-478 2HCl |
| Molecular Formula | C13H20Cl4N2O3 |
| Molecular Weight | 394.12 |
| Solubility | Soluble in Water/DMSO |
| Purity | ≥98% |
| Appearance | Yellow to brown Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD11840749 |
| SMILES | [O-][N+](CCCl)(CCCl)C(C=C1)=CC=C1C[C@H](N)C(O)=O.Cl.Cl |
| Target Point | HIF/HIF Prolyl-Hydroxylase |
| Passage | HIF |
| Background | PX-478 is a hypoxia-inducible factor-1α (HIF-1α) inhibitor with anticancer activity. |
| Biological Activity | PX-478 是有抗癌活性的缺氧诱导因子-1α (HIF-1α) 抑制剂，对一些癌细胞系 IC50 为 20-30 μM[1-2]。 |
| Data Literature Source | [1]. Palayoor ST，et al. PX-478，an inhibitor of hypoxia-inducible factor-1alpha，enhances radiosensitivity of prostate carcinoma cells. Int J Cancer. 2008 Nov 15;123(10):2430-2437. [2]. Agarwal S，et al. Inhibition of Hif1α prevents both trauma-induced and genetic heterotopic ossification. Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):E338-47 |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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