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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Ubiquitin > DegrasynCAS：856243-80-6
Molecular Formula：C19H18BrN3O
Molecular Weight：384.27
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 856243-80-6 |
| Name | Degrasyn |
| Molecular Formula | C19H18BrN3O |
| Molecular Weight | 384.27 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 604-604-1 |
| MDL | MFCD18839228 |
| SMILES | BrC1=CC=CC(/C=C(C(N[C@H](C2=CC=CC=C2)CCC)=O)\C#N)=N1 |
| Target Point | Bcr-Abl;Deubiquitinase（DUB） |
| Passage | Protein Tyrosine Kinase/RTK |
| Background | Degrasyn is a selective Deubiquitinase (DUB) inhibitor that also inhibits Bcr/Abl. |
| Biological Activity | Degrasyn 是可渗透细胞的 去泛素化酶(DUB) 抑制剂，直接抑制USP9x，USP5，USP14和UCH37的DUB活性。 Degrasyn 减弱抗细胞凋亡蛋白 Bcr-Abl 和 JAK2[1]。 |
| IC50 | 1.8μM(Bcr-Abl，in K562，BV-173 cells)[1] |
| Data Literature Source | [1]. Bartholomeusz GA，et al. Activation of a novel Bcr/Abl destruction pathway by WP1130 induces apoptosis of chronic myelogenous leukemia cells. Blood. 2007 Apr 15;109(8):3470-8. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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