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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Protein Tyrosine Kinase/PTK > FostamatinibCAS：901119-35-5
Molecular Formula：C23H26FN6O9P
Molecular Weight：580.46
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 901119-35-5 |
| Name | Fostamatinib |
| Molecular Formula | C23H26FN6O9P |
| Molecular Weight | 580.46 |
| Solubility | Soluble in DMSO ≥6mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 618-473-2 |
| MDL | MFCD16628163 |
| SMILES | COC1=CC(NC2=NC=C(C(NC3=NC(N4COP(O)(O)=O)=C(C=C3)OC(C)(C)C4=O)=N2)F)=CC(OC)=C1OC |
| Target Point | Syk |
| Passage | Protein Tyrosine Kinase/RTK |
| Background | Fostamatinib is a Syk inhibitor. |
| Biological Activity | Fostamatinib (formerly also known as R788; trade name: Tavalisse), a prodrug of the active metabolite R406, is an orally bioactive, potent and selective Syk inhibitor with potential anti-inflammatory activity. It inhibits Syk with an IC50 of 41 nM in a cell-free assay. On April 17th 2018, Fostamatinib was approved by the US FDA for the treatment of thrombocytopenia in adult patients with persistent or chronic immune thrombocytopenia (ITP).[1] |
| Data Literature Source | [1]. Blood. 2010 Dec 2;116(23):4894-905; Blood. 2008 Feb 15;111(4):2230-7. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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