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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > ApoptozoleCAS：1054543-47-3
Molecular Formula：C33H25F6N3O3
Molecular Weight：625.56
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1054543-47-3 |
| Name | Apoptozole |
| Molecular Formula | C33H25F6N3O3 |
| Molecular Weight | 625.56 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 604-604-1 |
| MDL | MFCD19443178 |
| SMILES | NC(C(C=C1)=CC=C1CN2C(C3=CC=C(OC)C=C3)=C(C4=CC=C(OC)C=C4)N=C2C5=CC(C(F)(F)F)=CC(C(F)(F)F)=C5)=O |
| Target Point | HSP70;Hsc70 |
| Passage | Cell Cycle;Metabolic Enzyme&Protease |
| Background | Apoptozole is a potent and selective inhibitor of HSP70 and Hsc70. |
| Biological Activity | Apoptozole (Apoptosis Activator VII) 是热激蛋白HSP70和Hsc70的抑制剂，与HSP70和Hsc70的Kd值分别为0.14 μM和0.21 μM。它能够诱导caspase依赖性的凋亡反应。[1] |
| Data Literature Source | [1] Williams DR，et al. Angew Chem Int Ed Engl. 2008，47(39):7466-9. [2] Ko SK，et al. Chem Biol. 2015，22(3):391-403. [3] Evans LE，et al. PLoS One. 2015，10(10):e0140006. |
| Unit | Piece |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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