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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > GW9662CAS：22978-25-2
Molecular Formula：C13H9ClN2O3
Molecular Weight：276.68
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 22978-25-2 |
| Name | GW9662 |
| Molecular Formula | C13H9ClN2O3 |
| Molecular Weight | 276.68 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 636-590-7 |
| MDL | MFCD01215270 |
| SMILES | O=C(NC1=CC=CC=C1)C2=CC([N+]([O-])=O)=CC=C2Cl |
| Target Point | PPAR |
| Passage | Cell Cycle;DNA Damage/DNA Repair;Metabolic Enzyme&Protease |
| Background | GW9662 is a potent and selective PPARγ antagonist. |
| Biological Activity | GW9662是有效，选择性的 PPARγ 拮抗剂，IC50值为3.3 nM，比PPARα和PPARδ的选择性高10倍和1000倍[1-4]。 |
| IC50 | PPARα:32nM;PPARγ:3.3nM;PPARδ:2000nM [1-4] |
| Data Literature Source | [1]. Leesnitzer LM，et al. Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662. Biochemistry. 2002 May 28;41(21):6640-50. [2]. Seargent JM，et al. GW9662，a potent antagonist of PPARgamma，inhibits growth of breast tumour cells and promotes the anticancer effects of the PPARgamma agonist rosiglitazone，independently of PPARgamma activation. Br J Pharmacol. 2004 Dec;143(8):933-7. [3]. Sato K，et al. PPARγ antagonist attenuates mouse immune-mediated bone marrow failure by inhibition of T cell function.Haematologica. 2016 Jan;101(1):57-67. [4]. Collino M，et al. The selective PPARgamma antagonist GW9662 reverses the protection of LPS in a model of renal ischemia-reperfusion. Kidney Int. 2005 Aug;68(2):529-36 |
| Unit | Piece |
| Specification | 5mg 10mM*1mL in DMSO 10mg 20mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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