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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > MAPK > SB-203580CAS：152121-47-6
Molecular Formula：C21H16FN3OS
Molecular Weight：377.43
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to light yellow Solid
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| CAS | 152121-47-6 |
| Name | SB-203580 |
| Molecular Formula | C21H16FN3OS |
| Molecular Weight | 377.43 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to light yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00922198 |
| SMILES | O=S(C1=CC=C(C2=NC(C3=CC=C(F)C=C3)=C(C4=CC=NC=C4)N2)C=C1)C |
| Target Point | p38 MAPK，LCK，GSK3β,PKBα，Autophagy, Mitophagy |
| Passage | MAPK;PI3K/Akt/mTOR;Stem Cells;Protein Tyrosine Kinase/RTK;Autophagy |
| Background | SB-203580 is a selective, ATP-competitive inhibitor of p38 MAPK that also inhibits LCK, GSK3β and PKα. SB-203580 is an activator of autophagy and mitophagy. |
| Biological Activity | SB 203580是一种广泛使用的 p38 MAPK 抑制剂， IC50 介于 0.3-0.5μM 之间。 对 p38 MAPK 的选择性比 PKB, LCK, 和 GSK-3β 高100倍。SB 203580能够以剂量依赖性方式抑制PDK1的活性，IC50在3-10μM范围内。[1-5] |
| Data Literature Source | [1]. Lali FV，et al. The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity，protein kinase B phosphorylation，and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activated protein kinase. J Biol Chem. 2000 Mar 10;275(10):7395-402. [2]. Birkenkamp KU，et al. The p38 MAP kinase inhibitor SB203580 enhances nuclear factor-kappa B transcriptional activity by a non-specific effect upon the ERK pathway. Br J Pharmacol. 2000 Sep;131(1):99-107. [3]. Su J，et al. SB203580，a p38 inhibitor，improved cardiac function but worsened lung injury and survival during Escherichia coli pneumonia in mice. J Trauma. 2010 Jun;68(6):1317-27. [4]. Badger AM，et al. Pharmacological profile of SB 203580，a selective inhibitor of cytokine suppressive binding protein/p38 kinase，in animal models of arthritis，bone resorption，endotoxin shock and immune function. J Pharmacol Exp Ther. 1996 Dec;279(3):1453-61. [5]. Lin Y，et al. Critical role of astrocytic interleukin-17 A in post-stroke survival and neuronal differentiation of neural precursor cells in adult mice. Cell Death Dis. 2016 Jun 23;7(6):e2273 |
| Unit | Piece |
| Specification | 10mg 20mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Alfhili MA, et. . Int J Occup Med Environ Health. 2022 Feb 15;35(1):1-11. doi: 10.13075/ijomeh.1896.01814.
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Induction of hemolysis and eryptosis by occupational pollutant nickel chloride is mediated through calcium influx and p38 MAP kinase signaling.
Click to check >>Author：Alfhili MA, Alamri HS, Alsughayyir J, Basudan AM.
IF：1.6760
Publish_to：Int J Occup Med Environ Health.
PMID：34524276
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