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Gilteritinib

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Cat.No：IG1000 Solarbio

CAS：1254053-43-4

Molecular Formula：C₂₉H₄₄N₈O₃

Molecular Weight：552.71

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light yellow to yellow Solid

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Product Information

CAS	1254053-43-4
Name	Gilteritinib
Molecular Formula	C₂₉H₄₄N₈O₃
Molecular Weight	552.71
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Light yellow to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD28144685
SMILES	NC(C1=NC(CC)=C(NC2CCOCC2)N=C1NC3=CC(OC)=C(N4CCC(N5CCN(C)CC5)CC4)C=C3)=O
InChIKey	GYQYAJJFPNQOOW-UHFFFAOYSA-N
InChI	InChI=1S/C29H44N8O3/c1-4-23-28(31-20-9-17-40-18-10-20)34-29(26(33-23)27(30)38)32-21-5-6-24(25(19-21)39-3)37-11-7-22(8-12-37)36-15-13-35(2)14-16-36/h5-6,19-20,22H,4,7-18H2,1-3H3,(H2,30,38)(H2,31,32,34)
PubChem CID	49803313
Target Point	FLT3
Passage	Angiogenesis; Protein Tyrosine Kinase/RTK
Background	Gilteritinib is a small molecule FLT3/AXL inhibitor.
Biological Activity	Gilteritinib (ASP2215) is a potent and ATP-competitive FLT3/AXL inhibitor with IC50s of 0.29 nM/0.73 nM， respectively.[1-2]
IC50	IC50: 0.29 nM (FLT3)[1]IC50: 0.35 nM (LTK)， 0.73 nM (AXL)， 1.2 nM (EML4-ALK)， 230 nM (c-KIT)[2]
Data Literature Source	[1]. ASP2215， a novel FLT3/AXL inhibitor: Preclinical evaluation in acute myeloid leukemia (AML). 2014 ASCO Annual Meeting. [2]. Mori M， et al. Gilteritinib， a FLT3/AXL inhibitor， shows antileukemic activity in mouse models of FLT3 mutated acute myeloid leukemia. Invest New Drugs. 2017 Oct;35(5):556-565.
Unit	Piece
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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