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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > GPCR & G Protein > Fingolimod HydrochlorideCAS：162359-56-0
Molecular Formula：C19H34ClNO2
Molecular Weight：343.93
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 162359-56-0 |
| Name | Fingolimod Hydrochloride |
| Molecular Formula | C19H34ClNO2 |
| Molecular Weight | 343.93 |
| Solubility | Soluble in Water/DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 680-631-1 |
| MDL | MFCD00939512 |
| SMILES | OCC(N)(CO)CCC1=CC=C(C=C1)CCCCCCCC.[H]Cl |
| InChIKey | SWZTYAVBMYWFGS-UHFFFAOYSA-N |
| InChI | InChI=1S/C19H33NO2.ClH/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22;/h9-12,21-22H,2-8,13-16,20H2,1H3;1H |
| PubChem CID | 107969 |
| Target Point | PAK1;S1P receptor |
| Passage | Cell Cycle; Cytoskeleton;GPCR & G Protein |
| Background | Fingolimod hydrochloride is an S1P antagonist. |
| Biological Activity | Fingolimod hydrochloride是鞘氨醇1-磷酸 (S1P) 拮抗剂, 在K562和NK细胞中的IC50 为0.033 nM[1]。 |
| IC50 | IC50: 0.033nM (S1P， in K562 andnK cells) [1] |
| Data Literature Source | [1]. Rolin J， et al. FTY720 and SEW2871 reverse the inhibitory effect of S1P on natural killer cell mediated lysis of K562 tumor cells and dendritic cells but not on cytokine release. Cancer Immunol Immunother. 2010， 59 (4) ， 575-586. [2]. Coldewey SM， et al. Elevation of serum sphingosine-1-phosphate attenuates impaired cardiac function in experimental sepsis. Sci Rep. 2016 Jun 9; 6:27594. [3]. Cipriani R， et al. FTY720 attenuates excitotoxicity and neuroinflammation. J Neuroinflammation. 2015 May 8; 12:86 |
| Unit | Piece |
| Specification | 50mg 100mg 250mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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