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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > EmpagliflozinCAS：864070-44-0
Molecular Formula：C23H27ClO7
Molecular Weight：450.91
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 864070-44-0 |
| Name | Empagliflozin |
| Molecular Formula | C23H27ClO7 |
| Molecular Weight | 450.91 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 620-176-8 |
| MDL | MFCD22566222 |
| SMILES | ClC(C=CC([C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)=C2)=C2CC(C=C3)=CC=C3O[C@H]4CCOC4 |
| InChIKey | OBWASQILIWPZMG-QZMOQZSNSA-N |
| InChI | InChI=1S/C23H27ClO7/c24-18-6-3-14(23-22(28)21(27)20(26)19(11-25)31-23)10-15(18)9-13-1-4-16(5-2-13)30-17-7-8-29-12-17/h1-6,10,17,19-23,25-28H,7-9,11-12H2/t17-,19+,20+,21-,22+,23-/m0/s1 |
| PubChem CID | 11949646 |
| Target Point | SGLT |
| Passage | Membrane Transporter&Ion Channel |
| Background | Empagliflozin is a selective sodium glucose cotransporter-2 (SGLT-2) inhibitor. |
| Biological Activity | Empagliflozin是一种选择性(SGLT-2抑制剂，抑制人SGLT-2的IC50 为3.1 nM[1-4]。 |
| Data Literature Source | [1]. Grempler R，et al. Empagliflozin，a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitors. Diabetes Obes Metab. 2012 Jan;14(1):83-90. [2]. Cheng ST，et al. The Effects of Empagliflozin，an SGLT2 Inhibitor，on Pancreatic β-Cell Mass and Glucose Homeostasis in Type 1 Diabetes. PLoS One. 2016 Jan 25;11(1):e0147391. [3]. Nikole J.ByrneBSc，et al. Empagliflozin Prevents Worsening of Cardiac Function in an Experimental Model of Pressure Overload-Induced Heart Failure. JACC Basic Transl Sci. 2017 Aug;2(4):347-354. [4]. Sakaeda T，et al. Susceptibility to serious skin and subcutaneous tissue disorders and skin tissue distribution of sodium-dependent glucose co-transporter type 2 (SGLT2) inhibitors. Int J Med Sci. 2018 Jun 13;15(9):937-943. |
| Unit | Bottle |
| Specification | 10mM*1mL in DMSO 50mg 100mg 250mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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