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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > GPCR & G Protein > A 779CAS：159432-28-7
Molecular Formula：C39H60N12O11
Molecular Weight：872.97
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 159432-28-7 |
| Name | A 779 |
| Molecular Formula | C39H60N12O11 |
| Molecular Weight | 872.97 |
| Solubility | Soluble in Water |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00672447 |
| SMILES | O=C(N[C@]([C@@H](C)CC)([H])C(N[C@H](C(N[C@H](C)C(O)=O)=O)CC1=CNC=N1)=O)[C@@H](NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC([C@@H](N)CC(O)=O)=O)=O)=O)CC2=CC=C(O)C=C2 |
| InChIKey | GZSZZUXDAPDPOR-NGIFJXEWSA-N |
| InChI | InChI=1S/C39H60N12O11/c1-6-20(4)31(37(60)49-28(15-23-17-43-18-45-23)34(57)46-21(5)38(61)62)51-35(58)27(14-22-9-11-24(52)12-10-22)48-36(59)30(19(2)3)50-33(56)26(8-7-13-44-39(41)42)47-32(55)25(40)16-29(53)54/h9-12,17-21,25-28,30-31,52H,6-8,13-16,40H2,1-5H3,(H,43,45)(H,46,57)(H,47,55)(H,48,59)(H,49,60)(H,50,56)(H,51,58)(H,53,54)(H,61,62)(H4,41,42,44)/t20-,21+,25-,26-,27-,28-,30-,31-/m0/s1 |
| PubChem CID | 10169886 |
| Target Point | Angiotensin Receptor |
| Passage | GPCR & G Protein |
| Background | A779 is A potent antagonist of G protein-coupled receptor Mas (Ang1-7 receptor). |
| Data Literature Source | [1]. Abuohashish HM，et al. Angiotensin (1-7) ameliorates the structural and biochemical alterations of ovariectomy-induced osteoporosis in rats via activation of ACE-2/Mas receptor axis. Sci Rep. 2017 May 23;7(1):2293. [2]. Abuohashish HM，et al. ACE-2/Ang1-7/Mas cascade mediates ACE inhibitor，captopril，protective effects in estrogen-deficient osteoporotic rats. Biomed Pharmacother. 2017 Aug;92:58-68. [3]. Yan WF，et al. Effects and related mechanism of angiotensin-(1-7) on Toll-like receptor 4-mediated oxidative stress in human umbilical vein endothelial cells. Zhonghua Xin Xue Guan Bing Za Zhi. 2017 Mar 24;45(3):223-229. |
| Unit | Piece |
| Specification | 5mg 10mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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