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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Apoptosis > Necrostatin-1CAS：4311-88-0
Molecular Formula：C13H13N3OS
Molecular Weight：259.33
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 4311-88-0 |
| Name | Necrostatin-1 |
| Molecular Formula | C13H13N3OS |
| Molecular Weight | 259.33 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-256-5 |
| MDL | MFCD00056916 |
| SMILES | O=C(C(CC1=CNC2=C1C=CC=C2)N3)N(C)C3=S |
| InChIKey | TXUWMXQFNYDOEZ-UHFFFAOYSA-N |
| InChI | InChI=1S/C13H13N3OS/c1-16-12(17)11(15-13(16)18)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,14H,6H2,1H3,(H,15,18) |
| PubChem CID | 2828334 |
| Target Point | Necroptosis;RIP kinase |
| Passage | Apoptosis;Immunology & Inflammation;Metabolic Enzyme&Protease |
| Background | Necrostatin-1 is a potent, selective and cell-permeable inhibitor of necroptosis. It acts by inhibiting the death domain receptor kinase RIP (RIP1) in the necroptosis pathway. |
| Biological Activity | Necrostatin-1是一种有效，选择性和可渗透细胞的坏死性凋亡 (necroptosis) 抑制剂，在Jurkat细胞中的 EC50 为490 nM。它通过抑制坏死性凋亡途径中的死亡域受体激酶RIP (RIP1) 起作用。 |
| Data Literature Source | [1]. Degterev A，et al. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol. 2005 Jul;1(2):112-9. [2]. Linkermann A，et al. The RIP1-kinase inhibitor necrostatin-1 prevents osmotic nephrosis and contrast-induced AKI in mice. J Am Soc Nephrol. 2013 Oct;24(10):1545-57. [3]. Huang C，et al. Shikonin kills glioma cells through necroptosis mediated by RIP-1. PLoS One. 2013 Jun 28;8(6):e66326. [4]. Feyen D，et al. Increasing short-term cardiomyocyte progenitor cell (CMPC) survival by necrostatin-1 did not further preserve cardiac function. Cardiovasc Res. 2013 Jul 1;99(1):83-91. [5]. Zhou K，et al. RIP1-RIP3-DRP1 pathway regulates NLRP3 inflammasome activation following subarachnoid hemorrhage. Exp Neurol. 2017 Sep;295:116-124. |
| Unit | Piece |
| Specification | 10mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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